Proton Pump Inhibitors: An Update Since their introduction in the late 1980s, proton pump inhibitors have demonstrated gastric acid suppression superior to that of histamine H 2-receptor blockers.
The clinical impact of these results must be assessed by further investigations, but a PPI treatment should not be added to the antiplatelet dual therapy without formal indication. A recent study has also suggested that proton pump inhibitors significantly decreased the effect of clopidogrel on platelets as tested by VASP phosphorylation. Also, the reduction of vitamin B 12 (by raising ) may increase bone fragility, an effect that may be offset by the consumption, or by the co-packaging, of about 100 mcg of B12 with the PPI. Theories as to the cause of the increase are the possibility that the reduction of stomach acid reduces the amount of calcium dissolved in the stomach or that PPIs may interfere with the breakdown and rebuilding of bone by interfering with the acid production of.
0 kommentar(er)
